{"schema_version":"1.0","type":"article","title":"IVF With 80% Fewer Shots: Ferring Buys Gameto","url":"https://drugnews.com.tw/articles/2026-10-31-ferring-gameto-fertilo-ivf-fewer-hormone-injections-en.html","markdown_url":"https://drugnews.com.tw/articles/2026-10-31-ferring-gameto-fertilo-ivf-fewer-hormone-injections-en.md","lang":"en","date":"2026-10-31","publish_at":"2026-10-31T08:00:00+08:00","updated_at":"2026-10-31","category":"商業分析系列","topic":"BD / 授權","tags":["IVF","fertility shots","Fertilo","Ferring","Gameto"],"summary":"IVF means 10-14 days of hormone shots. Ferring, which sells them, will pay up to $1.3825B for Gameto's 2-3 day Fertilo. Its US Phase 3 only races old-style IVM; no FDA approval before April 30, 2028.","key_points":["Ferring's October 27, 2026 deal to buy Gameto for up to $1.3825 billion is insurance for its fertility-shot business: Fertilo's US Phase 3 FIRST trial uses old-style MediCult IVM as its control rather than standard IVF, primary completion is estimated for May 2027, and Fertilo will not win FDA approval before April 30, 2028.","Fertilo matures eggs outside the body with iPSC-derived ovarian support cells, cutting hormone injections from 10-14 days to 2-3 days; in a 40-patient first-in-human study posted in April 2025, maturation was 70% vs 52% for old-style IVM and ongoing pregnancy per cycle 44% vs 20% (10 patients per arm).","Taiwan recorded 58,557 assisted reproduction treatments and 11,658 resulting babies in 2023, about 8.6% of its 135,571 births; Fertilo is not sold in Taiwan, and the conditional-approval fast lane in Taiwan's regenerative medicine acts, effective January 1, 2026, does not cover infertility."],"facts":[{"claim":"Maximum value of Ferring's acquisition of Gameto (incl. milestones)","value":1382.5,"unit":"USD million","as_of":"2026-10-27","source":"https://ferringusa.com/?press=ferring-pharmaceuticals-and-gameto-sign-agreement-for-proposed-acquisition"},{"claim":"Gameto total capital raised since 2020","value":127,"unit":"USD million","as_of":"2026-10-27","source":"https://www.biopharmadive.com/news/ferring-gameto-acquire-ivf-fertilo-womens-health/872904/"},{"claim":"Daily hormone self-injection in standard IVF","value":"10-14","unit":"days","as_of":"2025-01-30","source":"https://www.biospace.com/press-releases/gameto-announces-fda-ind-clearance-for-fertilo-the-first-ipsc-based-therapy-to-enter-u-s-phase-3-clinical-trials"},{"claim":"Hormone injection days with Fertilo","value":"2-3","unit":"days","as_of":"2025-01-30","source":"https://www.biospace.com/press-releases/gameto-announces-fda-ind-clearance-for-fertilo-the-first-ipsc-based-therapy-to-enter-u-s-phase-3-clinical-trials"},{"claim":"Patients in Fertilo first-in-human study (Mexico, Peru)","value":40,"unit":"patients","as_of":"2025-04-03","source":"https://www.medrxiv.org/content/10.1101/2025.04.02.25324702v1"},{"claim":"Egg maturation rate, Fertilo, randomized arm","value":70,"unit":"%","as_of":"2025-04-03","source":"https://www.medrxiv.org/content/10.1101/2025.04.02.25324702v1"},{"claim":"Egg maturation rate, old-style IVM, randomized arm","value":52,"unit":"%","as_of":"2025-04-03","source":"https://www.medrxiv.org/content/10.1101/2025.04.02.25324702v1"},{"claim":"Ongoing pregnancy per cycle, Fertilo","value":44,"unit":"%","as_of":"2025-04-03","source":"https://www.medrxiv.org/content/10.1101/2025.04.02.25324702v1"},{"claim":"Ongoing pregnancy per cycle, old-style IVM","value":20,"unit":"%","as_of":"2025-04-03","source":"https://www.medrxiv.org/content/10.1101/2025.04.02.25324702v1"},{"claim":"Date of first Fertilo baby (Lima, Peru)","value":"2024-12-16","unit":"date","as_of":"2026-10-27","source":"https://infobae.com/economia/2026/10/27/un-magnate-argentino-vendio-su-sexto-unicornio-por-mas-de-usd-1380-millones-la-emotiva-historia-que-inspiro-el-negocio"},{"claim":"Fertilo births reported by August 2025","value":5,"unit":"births","as_of":"2025-08-13","source":"https://www.biospace.com/press-releases/gametos-44m-series-c-to-help-redefine-reproductive-care-as-first-patients-recruited-for-pivotal-stem-cell-phase-3-trial"},{"claim":"Planned enrollment in FIRST Phase 3 (control: MediCult IVM)","value":500,"unit":"patients","as_of":"2026-10-07","source":"https://clinicaltrials.gov/study/NCT06858111"},{"claim":"FIRST estimated primary completion","value":"2027-05","unit":"year-month","as_of":"2026-10-07","source":"https://clinicaltrials.gov/study/NCT06858111"},{"claim":"FIRST estimated study completion","value":"2028-01","unit":"year-month","as_of":"2026-10-07","source":"https://clinicaltrials.gov/study/NCT06858111"},{"claim":"Ferring 2025 revenue (exceeded)","value":2.5,"unit":"EUR billion","as_of":"2026-03-10","source":"https://www.biospace.com/press-releases/for-the-first-time-ferring-reports-revenue-of-over-2-5-billion-in-2025"},{"claim":"Ferring 2025 revenue growth at constant exchange rates","value":10,"unit":"%","as_of":"2026-03-10","source":"https://www.biospace.com/press-releases/for-the-first-time-ferring-reports-revenue-of-over-2-5-billion-in-2025"},{"claim":"Merck KGaA 2025 fertility net sales","value":1457,"unit":"EUR million","as_of":"2026-03-05","source":"https://www.emdgroup.com/en/news/q4-2025-05-03-2026"},{"claim":"Merck KGaA 2025 fertility organic growth","value":0.4,"unit":"%","as_of":"2026-03-05","source":"https://www.emdgroup.com/en/news/q4-2025-05-03-2026"},{"claim":"Taiwan assisted reproduction treatments in 2023","value":58557,"unit":"treatments","as_of":"2025-12-28","source":"https://udn.com/news/story/7266/9230750"},{"claim":"Taiwan babies born via assisted reproduction in 2023","value":11658,"unit":"babies","as_of":"2025-12-28","source":"https://udn.com/news/story/7266/9230750"},{"claim":"Taiwan total births in 2023","value":135571,"unit":"babies","as_of":"2024-01-10","source":"https://cdn.technews.tw/2024/01/10/taiwan-number-of-births-2023"},{"claim":"Taiwan IVF subsidy 3.0 cap for women under 39","value":150000,"unit":"TWD","as_of":"2026-04-22","source":"https://udn.com/news/story/7266/9457306"},{"claim":"Babies born under Taiwan IVF subsidy through 2026-04-12","value":34219,"unit":"babies","as_of":"2026-04-22","source":"https://udn.com/news/story/7266/9457306"},{"claim":"Taiwan regenerative medicine acts full effective date","value":"2026-01-01","unit":"date","as_of":"2026-09-02","source":"https://geneonline.news/how-taiwans-regenerative-medicine-acts-offer-a-lifeline-to-critically-ill-patients-gct-month-007-sep-2026/"},{"claim":"Taiwan 2023 live birth rate after single-embryo transfer (own gametes)","value":36.9,"unit":"%","as_of":"2026-05-07","source":"https://www.cna.com.tw/news/ahel/202605070158.aspx"}],"sections":["01 | Why the two weeks of shots never went away","02 | Fertilo moves the ripening into a dish","03 | Does it work for patients? Strong numbers, 40 patients","04 | Why Ferring would buy a threat to its own business","05 | What it means for Taiwan, an IVF-heavy market","References"],"references":[{"title":"Ferring Pharmaceuticals and Gameto sign agreement for proposed acquisition","source":"Ferring Pharmaceuticals","date":"2026-10-27","url":"https://ferringusa.com/?press=ferring-pharmaceuticals-and-gameto-sign-agreement-for-proposed-acquisition"},{"title":"Ferring to acquire next-gen IVF startup Gameto for up to $1.4B","source":"BioPharma Dive","date":"2026-10-27","url":"https://www.biopharmadive.com/news/ferring-gameto-acquire-ivf-fertilo-womens-health/872904/"},{"title":"Un magnate argentino vendió su sexto unicornio por más de USD 1.380 millones","source":"Infobae","date":"2026-10-27","url":"https://infobae.com/economia/2026/10/27/un-magnate-argentino-vendio-su-sexto-unicornio-por-mas-de-usd-1380-millones-la-emotiva-historia-que-inspiro-el-negocio"},{"title":"Fertilo In Vitro Research Study and Trial (FIRST, NCT06858111","source":"ClinicalTrials.gov","date":"2026-10-07","url":"https://clinicaltrials.gov/study/NCT06858111"},{"title":"Gameto's $44M Series C as first patients recruited for pivotal stem cell Phase 3 trial","source":"BioSpace","date":"2025-08-13","url":"https://www.biospace.com/press-releases/gametos-44m-series-c-to-help-redefine-reproductive-care-as-first-patients-recruited-for-pivotal-stem-cell-phase-3-trial"},{"title":"Gameto Announces FDA IND Clearance for Fertilo","source":"BioSpace","date":"2025-01-30","url":"https://www.biospace.com/press-releases/gameto-announces-fda-ind-clearance-for-fertilo-the-first-ipsc-based-therapy-to-enter-u-s-phase-3-clinical-trials"},{"title":"Fertilo first-in-human study preprint (DOI 10.1101/2025.04.02.25324702","source":"medRxiv","date":"2025-04-03","url":"https://www.medrxiv.org/content/10.1101/2025.04.02.25324702v1"},{"title":"Gameto Reports Positive Results for IVF Alternative Technology That Reduces Hormone Treatments","source":"Femtech Insider","date":"2025-04-08","url":"https://femtechinsider.com/gameto-reports-positive-results-for-ivf-alternative-technology-that-reduces-hormone-treatments"},{"title":"For the First Time, Ferring Reports Revenue of Over €2.5 Billion in 2025","source":"Ferring Pharmaceuticals (BioSpace","date":"2026-03-10","url":"https://www.biospace.com/press-releases/for-the-first-time-ferring-reports-revenue-of-over-2-5-billion-in-2025"},{"title":"Merck KGaA, Darmstadt, Germany: Guidance for 2025 Delivered, Growth Foundation in Place","source":"Merck KGaA","date":"2026-03-05","url":"https://www.emdgroup.com/en/news/q4-2025-05-03-2026"},{"title":"人工生殖增幅緩 專家：對象飽和、缺乏生育意願 (Taiwan 2023 assisted reproduction data","source":"United Daily News (CNA","date":"2025-12-28","url":"https://udn.com/news/story/7266/9230750"},{"title":"2023 年出生數跌破低推估值 14 萬 (Taiwan 2023 births","source":"TechNews","date":"2024-01-10","url":"https://cdn.technews.tw/2024/01/10/taiwan-number-of-births-2023"},{"title":"人工生殖補助新生兒突破3萬名 (Taiwan IVF subsidy 3.0","source":"United Daily News","date":"2026-04-22","url":"https://udn.com/news/story/7266/9457306"},{"title":"再生醫療雙法三讀 (Taiwan regenerative medicine acts pass","source":"The Reporter","date":"2024-06-04","url":"https://www.twreporter.org/a/regenerative-medicine-legislation-passed"},{"title":"How Taiwan's Regenerative Medicine Acts Offer a Lifeline to Critically Ill Patients","source":"GeneOnline","date":"2026-09-02","url":"https://geneonline.news/how-taiwans-regenerative-medicine-acts-offer-a-lifeline-to-critically-ill-patients-gct-month-007-sep-2026/"},{"title":"試管植入胚胎越多越好？國健署示警藏早產風險 (Taiwan 2023 IVF live birth rates","source":"Central News Agency","date":"2026-05-07","url":"https://www.cna.com.tw/news/ahel/202605070158.aspx"}],"images":[{"alt":"Fig. 1 | Fewer shots, egg grows in a dish","url":"https://drugnews.com.tw/assets/articles/ferring-gameto-fertilo-ivf-fewer-hormone-injections-en/figure-01.png"},{"alt":"Fig. 2 | Fertilo beat old-style IVM","url":"https://drugnews.com.tw/assets/articles/ferring-gameto-fertilo-ivf-fewer-hormone-injections-en/figure-02.png"},{"alt":"Fig. 3 | Three ways to get a mature egg","url":"https://drugnews.com.tw/assets/articles/ferring-gameto-fertilo-ivf-fewer-hormone-injections-en/figure-03.png"},{"alt":"Fig. 4 | Fertilo's road to the US","url":"https://drugnews.com.tw/assets/articles/ferring-gameto-fertilo-ivf-fewer-hormone-injections-en/figure-04.png"}],"cover_image":"https://drugnews.com.tw/assets/articles/ferring-gameto-fertilo-ivf-fewer-hormone-injections-en/cover.png","publisher":{"name":"Drugnews｜藥時事","url":"https://drugnews.com.tw/","profile":"https://drugnews.com.tw/brand-profile.json"},"citation":"Drugnews｜藥時事（2026-10-31）。IVF With 80% Fewer Shots: Ferring Buys Gameto。https://drugnews.com.tw/articles/2026-10-31-ferring-gameto-fertilo-ivf-fewer-hormone-injections-en.html","disclaimer":"This article is intended for industry research and knowledge sharing only. It does not constitute investment, medical, fundraising, or individual stock advice.","translations":{},"relationship":"independent_editorial","disclosure_url":"https://drugnews.com.tw/policy/"}