{ "research_parent_version": "ADC-20261007-R1", "presentation_version": "ADC-20261007-R1-LAYERED-HTML-R2-1.0", "as_of": "2026-10-07", "calculations": [ { "id": "CALC_TOP1_ADC", "label": "ADC後隊列TOP1突變比例", "operation": "ratio_pct", "input_ids": [ "TOP1_ADC_NUM", "TOP1_ADC_DEN" ], "result": 0.12903225806451613, "unit": "%", "interpretation": "4/31；result為0–1小數供Excel百分比格式。選定回溯隊列，非一般發生率。", "source_ids": [ "R03" ] }, { "id": "CALC_TOP1_NO_ADC", "label": "另一未接受ADC隊列TOP1突變比例", "operation": "ratio_pct", "input_ids": [ "TOP1_NO_ADC_NUM", "TOP1_NO_ADC_DEN" ], "result": 0.007142857142857143, "unit": "%", "interpretation": "3/420；result為0–1小數。兩個獨立隊列，非配對或隨機對照。", "source_ids": [ "R03" ] }, { "id": "CC01", "label": "Breast09兩組中位PFS差", "operation": "difference", "input_ids": [ "DB09_PFS_EXP", "DB09_PFS_CTRL" ], "result": 13.8, "unit": "月", "interpretation": "同一試驗兩組中位數差，不是每人延長時間；不跨試驗排行。", "source_ids": [ "C01" ] }, { "id": "CC02", "label": "Breast05三年iDFS百分點差", "operation": "difference", "input_ids": [ "DB05_IDFS_3Y_EXP", "DB05_IDFS_3Y_CTRL" ], "result": 8.7, "unit": "百分點", "interpretation": "原始百分比92.4−83.7＝8.7百分點，不是相對風險或治癒率。", "source_ids": [ "C02" ] }, { "id": "CC03", "label": "FDA版Breast11 pCR百分點差", "operation": "difference", "input_ids": [ "DB11_PCR_EXP", "DB11_PCR_CTRL" ], "result": 11.0, "unit": "百分點", "interpretation": "FDA原始67.3−56.3＝11.0百分點；pCR不是EFS或OS。", "source_ids": [ "C02" ] }, { "id": "CALC_HDP101_ORR", "label": "HDP101可評估cohorts 5–9 ORR", "operation": "ratio_pct", "input_ids": [ "HDP101_ORR_NUM", "HDP101_ORR_DEN" ], "result": 0.41935483870967744, "unit": "%", "interpretation": "13/31；result為0–1小數。不是全體53人安全群或隨機比較效果。", "source_ids": [ "C12" ] }, { "id": "CALC_DB09_COMPARISON_N", "label": "Breast09此次兩組比較人數", "operation": "sum", "input_ids": [ "DB09_N_EXP", "DB09_N_CTRL" ], "result": 770.0, "unit": "人", "interpretation": "383＋387＝770；全試驗含第三臂共1157人，分別保存。", "source_ids": [ "C01", "C15" ] }, { "id": "CALC_TX03_MAX", "label": "Merck與第一三共原約最高條件對價", "operation": "sum", "input_ids": [ "TX03_UPFRONT", "TX03_CONTINUATION_ORIGINAL", "TX03_MILESTONES" ], "result": 22000.0, "unit": "百萬美元", "interpretation": "4000＋1500＋16500；原約條件全部達成，排除權利金與研發分攤；非已付款。", "source_ids": [ "D01" ] }, { "id": "CALC_TX03_SIGNING_SHARE", "label": "Merck與第一三共原約簽約金配置", "operation": "ratio_pct", "input_ids": [ "TX03_UPFRONT", "TX03_MAX" ], "result": 0.18181818181818182, "unit": "%", "interpretation": "result為0–1小數；簽約時結構，不是目前已付比例、成功率或現值。", "source_ids": [ "D01" ] }, { "id": "CALC_TX03_PAID", "label": "Merck與第一三共已披露累計付款", "operation": "sum", "input_ids": [ "TX03_PAID_UPFRONT", "TX03_PAID_CONT_2024", "TX03_PAID_CONT_2025" ], "result": 5500.0, "unit": "百萬美元", "interpretation": "4000＋750＋750；不含研發分攤、可能退款及未披露付款。", "source_ids": [ "D02" ] }, { "id": "CALC_TX05_MAX", "label": "Gilead研究選擇權最高對價", "operation": "sum", "input_ids": [ "TX05_UPFRONT", "TX05_OPTION_FEE", "TX05_MILESTONES" ], "result": 465.0, "unit": "百萬美元", "interpretation": "20＋30＋415；附行權及里程碑條件，不確認條件付款已發生。", "source_ids": [ "D14" ] }, { "id": "CALC_TX05_SIGNING_SHARE", "label": "Gilead研究約簽約金配置", "operation": "ratio_pct", "input_ids": [ "TX05_UPFRONT", "TX05_MAX" ], "result": 0.043010752688172046, "unit": "%", "interpretation": "result為0–1小數；不與2026收購或目前已付款混比。", "source_ids": [ "D14" ] }, { "id": "CALC_TX06_MAX", "label": "Gilead收購最高公告對價", "operation": "sum", "input_ids": [ "TX06_UPFRONT", "TX06_MILESTONES" ], "result": 5000.0, "unit": "百萬美元", "interpretation": "3150＋1850；交割附慣例調整、里程碑附條件；SEC約3200為另一口徑。", "source_ids": [ "D15" ] }, { "id": "CALC_SALES_TRODELVY_YOY_2024", "label": "Trodelvy 2024淨產品銷售同比", "operation": "growth_rate", "input_ids": [ "SALES_TRODELVY_2024", "SALES_TRODELVY_2023" ], "formula": "(current_year / previous_year - 1) × 100%", "substitution": "(1315 / 1063 - 1) × 100%", "result": 0.23706491063029156, "result_pct": 23.706491063029155, "display_pct": 23.7, "unit": "%", "interpretation": "result為0–1小數供Excel百分比格式；display_pct為依已披露百萬美元值重算、四捨五入至一位小數。", "source_ids": [ "D35" ], "label_en": "Trodelvy 2024 year-on-year net product sales growth", "formula_ratio": "current_year / previous_year - 1", "result_storage_unit": "dimensionless ratio; apply percentage display to result", "result_pct_unit": "percent (%) expressed on the 0–100 percentage scale", "interpretation_en": "The result field stores the dimensionless ratio for percentage formatting. result_pct multiplies that ratio by 100; display_pct rounds the recalculated percentage to one decimal place using the disclosed USD-million totals.", "method_note": "披露原值以百萬美元列示；衍生同比不是未四捨五入底層數據。", "method_note_en": "Recalculated from reported USD-million totals; this is not a calculation from undisclosed unrounded amounts." }, { "id": "CALC_SALES_TRODELVY_YOY_2025", "label": "Trodelvy 2025淨產品銷售同比", "operation": "growth_rate", "input_ids": [ "SALES_TRODELVY_2025", "SALES_TRODELVY_2024" ], "formula": "(current_year / previous_year - 1) × 100%", "substitution": "(1397 / 1315 - 1) × 100%", "result": 0.06235741444866916, "result_pct": 6.235741444866916, "display_pct": 6.2, "unit": "%", "interpretation": "result為0–1小數供Excel百分比格式；display_pct為依已披露百萬美元值重算、四捨五入至一位小數。", "source_ids": [ "D35" ], "label_en": "Trodelvy 2025 year-on-year net product sales growth", "formula_ratio": "current_year / previous_year - 1", "result_storage_unit": "dimensionless ratio; apply percentage display to result", "result_pct_unit": "percent (%) expressed on the 0–100 percentage scale", "interpretation_en": "The result field stores the dimensionless ratio for percentage formatting. result_pct multiplies that ratio by 100; display_pct rounds the recalculated percentage to one decimal place using the disclosed USD-million totals.", "method_note": "披露原值以百萬美元列示；衍生同比不是未四捨五入底層數據。", "method_note_en": "Recalculated from reported USD-million totals; this is not a calculation from undisclosed unrounded amounts." } ] }