Source ID: R09
Original URL: https://heidelberg-pharma.com/images/managed/HDP-101-01_AACR2024_final.pdf
Source date (attachment preserved): 2024
Data date (attachment preserved): 2024年AACR海報；本稿僅引用機制段落
Checked at: 2026-10-07T18:42:25+08:00
Timezone: Asia/Taipei
Retrieval mode: public_url_web_tool
Read level: 原 URL 一頁 AACR 2024 海報 PDF 文字；僅 Introduction / Background 機制段
Access result: 正常取得原 URL PDF 文字
Original raw artifact SHA256: null

LOCATORS (actual reading positions):
PDF 第1頁 Introduction L24–27；Background L30–35；年份與 poster CT067 L44–46

MINIMUM VERBATIM EXCERPT (only this block is source prose):
carries a synthetic amanitin payload. Amanitin inhibits RNA polymerase II

EXTRACTED FACTUAL FIELDS (not a reconstructed quotation):
[
  {
    "locator": "p1 Background L30–35",
    "drug": "HDP-101",
    "target": "BCMA",
    "payload": "synthetic amanitin",
    "payload_target": "RNA polymerase II",
    "action": "抑制轉錄；此處只作機制辨識，不作臨床增益證明"
  }
]

SCOPE / PRECISE GAP (reviewer description, not source prose):
支持 HDP-101 合成 amanitin / RNA polymerase II 機制；2024 海報較舊的臨床數據完全不作 2026 人體進展證據。

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