:root{color-scheme:light;--ink:#12313c;--deep:#103e48;--deep-2:#0c303a;--muted:#61767b;--line:#d5dfde;--copper:#a36037;--copper-light:#efb48e;--paper:#fafbf9;--serif:"Noto Serif TC","Songti TC","Noto Serif CJK TC",Georgia,serif;--sans:-apple-system,BlinkMacSystemFont,"Segoe UI","Noto Sans TC","Noto Sans CJK TC",sans-serif}
*{box-sizing:border-box}html{font-family:var(--sans);color:var(--ink);line-height:1.6;scroll-behavior:smooth;scroll-padding-top:104px}body{margin:0;background:var(--paper);-webkit-font-smoothing:antialiased}h1,h2,h3,p{margin:0}a{color:inherit;text-decoration:none}button,input{font:inherit}button{cursor:pointer}svg{width:22px;height:22px;flex-shrink:0}a:focus-visible,button:focus-visible,input:focus-visible{outline:3px solid #568baa;outline-offset:5px}.wrap{width:min(1280px,calc(100% - 96px));margin:0 auto}.skip-link{position:fixed;top:-80px;left:20px;z-index:100;background:var(--deep);color:white;padding:10px 16px}.skip-link:focus{top:12px}.site-header{position:sticky;top:0;z-index:25;background:rgba(250,251,249,.97);border-bottom:1px solid var(--line);backdrop-filter:blur(16px);transition:box-shadow .25s}.site-header.is-scrolled{box-shadow:0 6px 26px #12313c0d}.reading-progress{position:absolute;height:2px;background:var(--copper);width:100%;left:0;bottom:-1px;transform:scaleX(0);transform-origin:left;pointer-events:none}.nav-inner{height:78px;display:flex;align-items:center;justify-content:space-between;gap:22px}.brand{display:flex;align-items:center;gap:11px;white-space:nowrap}.brand img{display:block;width:36px;height:36px}.brand span{font-family:var(--serif);font-size:21px;font-weight:700;letter-spacing:-.02em}.nav-links{display:flex;align-items:center;gap:23px}.nav-links a,.nav-search{position:relative;font-size:13px;font-weight:500;padding:12px 0;white-space:nowrap;transition:color .2s}.nav-links a::after{content:"";position:absolute;bottom:3px;left:0;right:0;height:2px;background:var(--copper);transform:scaleX(0);transform-origin:left;transition:transform .2s}.nav-links a[aria-current=page]::after,.nav-links a:hover::after{transform:scaleX(1)}.nav-links a[aria-current=page]{font-weight:700}.nav-links .nav-depth{color:var(--copper);font-weight:700}.nav-search{display:flex;align-items:center;gap:5px;color:var(--ink);border:0;background:none}.nav-search svg{width:17px;height:17px}.nav-search:hover{color:var(--copper)}.mobile-actions{display:none;align-items:center;gap:8px}.nav-menu{border:1px solid var(--line);border-radius:2px;color:var(--ink);background:transparent;min-height:42px;padding:0 12px;display:flex;align-items:center;gap:8px;font-size:13px}.menu-lines{width:15px;height:10px;border-top:1px solid currentColor;border-bottom:1px solid currentColor}.nav-menu[aria-expanded=true]{background:var(--deep);color:white}.mobile-search{border:0;color:var(--ink);background:none;width:42px;height:42px;display:grid;place-items:center}
.edition-heading{display:flex;align-items:flex-end;justify-content:space-between;gap:20px;padding:35px 0 26px}.edition-title{display:flex;align-items:baseline;gap:23px}.edition-title h2{font-family:var(--serif);font-size:48px;line-height:1.25;letter-spacing:-.04em}.edition-en{font:italic 25px Georgia,serif;color:var(--copper)}.edition-right{display:flex;align-items:center;gap:24px;padding-bottom:7px}.edition-right p{font-size:12px;color:var(--muted);letter-spacing:.1em}.text-link{display:inline-flex;align-items:center;gap:9px;font-size:13px;font-weight:650;white-space:nowrap}.text-link svg{width:19px;height:19px;transition:transform .2s}.text-link:hover svg{transform:translate(3px,-2px)}.text-link:hover{color:var(--copper)}
.lead-feature{display:grid;grid-template-columns:minmax(0,1.18fr) minmax(0,1fr);min-height:504px;background:white;outline:1px solid #dbe3e1;position:relative;isolation:isolate}.feature-art{position:relative;display:flex;align-items:center;justify-content:center;background:#fafafa;overflow:hidden;min-width:0}.art-topline{position:absolute;top:27px;left:30px;right:30px;display:flex;align-items:center;justify-content:space-between;gap:15px;font-size:10px;letter-spacing:.13em;color:#6f8285;z-index:2}.art-topline span:first-child{display:flex;align-items:center;gap:8px}.art-topline span:first-child::before{content:"";width:6px;height:6px;background:var(--copper);border-radius:50%}.feature-image{display:block;width:100%;height:auto;max-height:100%;object-fit:contain;transition:filter .35s}.art-bottomline{position:absolute;bottom:27px;left:30px;right:30px;display:flex;align-items:center;justify-content:space-between;color:var(--muted);font-size:11px;letter-spacing:.04em}.art-bottomline span:first-child{border-bottom:1px solid #bfcfcf;padding-bottom:5px}.art-open{display:grid;place-items:center;width:39px;height:39px;border:1px solid #b8c9ca;border-radius:50%;color:var(--deep);background:rgba(255,255,255,.8);transition:background .2s,color .2s,transform .2s}.feature-art:hover .art-open{background:var(--deep);color:white;transform:rotate(-5deg)}.feature-copy{position:relative;display:flex;flex-direction:column;justify-content:center;align-items:flex-start;padding:32px 38px 34px;background:var(--deep);color:#fff;min-width:0;overflow:hidden}.feature-meta{display:flex;flex-wrap:wrap;align-items:center;gap:13px;margin-bottom:16px;color:#c6d7d9;font-size:11px;letter-spacing:.1em}.feature-meta .tag{display:inline-block;border:1px solid #648087;color:#e1ebeb;padding:3px 9px;letter-spacing:.03em}.feature-copy h2{font-family:var(--serif);font-size:33px;line-height:1.47;font-weight:700;letter-spacing:-.025em;margin-bottom:19px;overflow-wrap:break-word}.feature-copy h2 .drugname{display:block;color:var(--copper-light);font-family:Georgia,var(--serif);font-size:48px;line-height:1.04;font-weight:400;letter-spacing:-.035em;margin-bottom:10px}.feature-copy h2 .title-unit{display:inline}.feature-copy h2 .keep{display:inline-block;white-space:nowrap}.feature-copy .lede{font-size:13px;line-height:1.95;color:#c3d5d8;margin-bottom:23px;max-width:42em}.feature-actions{display:flex;align-items:center;justify-content:space-between;width:100%;gap:18px}.read-button{display:inline-flex;align-items:center;justify-content:space-between;gap:34px;min-height:45px;padding:0 17px;background:#f7f9f6;color:var(--deep);font-size:13px;font-weight:700;border:1px solid #f7f9f6;transition:background .2s,color .2s}.read-button svg{width:19px}.read-button:hover{background:var(--copper-light);border-color:var(--copper-light)}.feature-actions .section-wordmark{font:italic 14px Georgia,serif;color:#a3bdc1;letter-spacing:.02em}.lead-feature::after{position:absolute;content:"";height:4px;left:0;bottom:0;width:74px;background:var(--copper);z-index:3}.feature-copy h2 a:hover{color:inherit}.feature-copy h2 a:focus-visible{outline-color:var(--copper-light)}
.recent-section{padding:31px 0 50px;border-bottom:1px solid var(--line)}.section-heading{display:flex;align-items:center;justify-content:space-between;gap:20px;margin-bottom:21px}.section-heading h2{font-family:var(--serif);font-size:27px;line-height:1.3;font-weight:650}.section-heading h2 small{font:italic 15px Georgia,serif;color:var(--muted);margin-left:13px;vertical-align:middle}.news-grid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:0;border-top:1px solid var(--line);border-bottom:1px solid var(--line)}.news-card{display:flex;flex-direction:column;padding:18px 22px 17px;position:relative;min-width:0;isolation:isolate;border-right:1px solid var(--line);transition:background .2s}.news-card:first-child{padding-left:0}.news-card:last-child{padding-right:0;border-right:0}.news-card::after{content:"";height:2px;position:absolute;bottom:-1px;left:0;right:0;background:var(--copper);transform:scaleX(0);transform-origin:left;transition:transform .25s}.news-card:hover::after,.news-card:focus-visible::after{transform:scaleX(1)}.news-card:hover{background:#f2f5f1}.news-meta{display:flex;justify-content:space-between;align-items:baseline;gap:9px;margin-bottom:11px}.news-meta time{font-size:11px;font-variant-numeric:tabular-nums;color:var(--muted);letter-spacing:.07em}.news-number{font:italic 24px Georgia,serif;color:#98aaa9}.news-card h3{font-size:16px;font-weight:650;line-height:1.7;letter-spacing:.012em;margin-bottom:15px}.news-cta{display:flex;justify-content:space-between;align-items:center;gap:10px;margin-top:auto;color:var(--muted);font-size:11px}.news-cta .arrow{display:grid;place-items:center}.news-cta svg{width:18px;height:18px;transition:transform .2s}.news-card:hover .news-cta{color:var(--copper)}.news-card:hover .news-cta svg{transform:translateX(4px)}
.series-section{padding:57px 0 55px}.series-heading{align-items:flex-end;margin-bottom:27px}.series-heading h2{font-size:38px;letter-spacing:-.025em}.series-heading p{font-size:14px;color:var(--muted)}.series-layout{display:grid;grid-template-columns:minmax(0,.9fr) minmax(0,1.1fr);gap:38px}.series-tabs{border-top:1px solid var(--line);display:flex;flex-direction:column}.series-tab{min-height:77px;display:grid;grid-template-columns:41px minmax(0,1fr) 33px;align-items:center;gap:17px;padding:15px 18px;background:transparent;border:0;border-bottom:1px solid var(--line);color:var(--ink);text-align:left;transition:background .2s,color .2s}.series-index{font:italic 21px Georgia,serif;color:var(--copper)}.series-name{font-size:20px;font-weight:550}.series-tab .circle-arrow{display:grid;place-items:center;width:30px;height:30px;border:1px solid transparent;border-radius:50%;transition:transform .2s,border-color .2s}.series-tab .circle-arrow svg{width:19px;height:19px}.series-tab:hover .circle-arrow{border-color:#9eb2b6;transform:rotate(-35deg)}.series-tab:hover{background:#eef3f0}.series-tab.is-active{background:var(--deep);color:white;border-bottom-color:var(--deep)}.series-tab.is-active .series-index{color:var(--copper-light)}.series-tab.is-active .circle-arrow{border-color:#718f93;transform:rotate(-35deg)}.series-panel{position:relative;background:#edf2ee;border:1px solid #d8e2dc;display:flex;flex-direction:column;justify-content:center;padding:35px 40px;min-width:0;overflow:hidden;isolation:isolate}.series-panel::before{content:"";position:absolute;left:0;top:0;width:5px;height:64px;background:var(--copper)}.panel-number{position:absolute;right:26px;top:-2px;font:italic 157px Georgia,serif;color:#d8e3dc;z-index:-1;line-height:1;letter-spacing:-.08em;pointer-events:none}.eyebrow{font-size:10px;color:var(--copper);letter-spacing:.15em;font-weight:650;text-transform:uppercase}.series-panel .eyebrow{margin-bottom:24px}.series-panel h3{font-family:var(--serif);font-size:36px;line-height:1.4;font-weight:600;margin-bottom:16px;max-width:95%}.series-panel .description{font-size:16px;line-height:1.95;max-width:30em;color:#486368;min-height:6em}.series-panel .series-link{display:inline-flex;align-self:flex-start;align-items:center;gap:20px;border-bottom:1px solid var(--deep);padding:9px 0;margin-top:15px;font-size:13px;font-weight:650;transition:color .2s,gap .2s}.series-link:hover{color:var(--copper);gap:28px}.series-link svg{width:20px;height:20px}.series-help{display:flex;align-items:flex-start;gap:30px;margin-top:23px;color:var(--muted);font-size:12px;line-height:1.9}.series-help p{max-width:850px}.series-help .text-link{margin-left:auto;font-size:12px;margin-top:1px}
.editorial-section{border-top:1px solid var(--line);border-bottom:1px solid var(--line);padding:43px 0 39px;background:#fff}.editorial-layout{display:grid;grid-template-columns:180px 1fr;gap:45px;align-items:start}.editorial-label{padding-top:9px}.editorial-label p:last-child{font-family:var(--serif);font-size:21px;margin-top:10px}.editorial-copy h2{font-family:var(--serif);font-weight:550;font-size:29px;line-height:1.65;letter-spacing:.01em}.editorial-copy h2 .accent{color:var(--copper)}.editorial-links{display:flex;flex-wrap:wrap;gap:27px;margin-top:22px;font-size:12px}.editorial-links a{display:flex;align-items:center;gap:7px;border-bottom:1px solid #bacccc;padding-bottom:4px}.editorial-links svg{width:14px;height:14px}.editorial-links a:hover{color:var(--copper);border-color:var(--copper)}
.subscribe-section{padding:54px 0 48px}.subscribe-panel{position:relative;background:var(--deep);color:white;display:grid;grid-template-columns:1fr auto;gap:44px;align-items:center;padding:45px 46px;overflow:hidden;isolation:isolate}.subscribe-panel::after{content:"";position:absolute;width:300px;height:300px;border:1px solid #ffffff14;border-radius:50%;right:-75px;top:-150px;box-shadow:0 0 0 38px #ffffff06,0 0 0 78px #ffffff04;z-index:-1;pointer-events:none}.subscribe-panel .eyebrow{color:var(--copper-light);margin-bottom:13px}.subscribe-panel h2{font-family:var(--serif);font-size:38px;line-height:1.4;font-weight:550;margin-bottom:17px}.subscribe-panel .subscription-copy{max-width:660px;font-size:14px;line-height:1.95;color:#bed0d3}.subscribe-action{display:flex;flex-direction:column;align-items:flex-start;gap:15px}.subscribe-action .read-button{background:var(--copper-light);border-color:var(--copper-light);min-height:51px;gap:25px}.subscribe-action .read-button:hover{background:#ffe1cc;border-color:#ffe1cc}.subscribe-action>span{font-size:11px;color:#b1c7cc;letter-spacing:.03em}.social-row{display:flex;align-items:center;justify-content:space-between;gap:20px;padding-top:24px}.social-row p{font-size:12px;color:var(--muted)}.social-links{display:flex;gap:23px;flex-wrap:wrap;font-size:12px}.social-links a{display:flex;align-items:center;gap:7px}.social-links a:hover{color:var(--copper)}.social-links svg{width:14px;height:14px}.site-footer{padding:26px 0;background:#edf1ed;border-top:1px solid var(--line)}.footer-top{display:flex;align-items:flex-start;justify-content:space-between;gap:28px;font-size:11px;color:var(--muted)}.footer-brand{font-family:var(--serif);font-size:16px;color:var(--ink);margin-bottom:9px}.footer-disclaimer{max-width:600px}.footer-links{display:flex;gap:16px;flex-wrap:wrap;max-width:440px;justify-content:flex-end}.footer-links a:hover{text-decoration:underline}.privacy-row{display:flex;align-items:center;justify-content:space-between;gap:20px;margin-top:19px;padding-top:15px;border-top:1px solid #d9e0d9;color:var(--muted);font-size:10px}.privacy-links{display:flex;gap:17px;align-items:center}.privacy-links button{border:0;background:none;font-size:inherit;padding:0;color:inherit;text-decoration:underline}
.search-dialog{max-width:min(670px,calc(100vw - 36px));width:670px;padding:30px;border:1px solid #adc2c4;background:var(--paper);color:var(--ink);box-shadow:0 24px 100px #103e4855;border-radius:3px;max-height:85vh;overflow:auto}.search-dialog::backdrop{background:#0c303a88;backdrop-filter:blur(4px)}.search-title{display:flex;align-items:center;justify-content:space-between;gap:24px;margin-bottom:10px}.search-title h2{font-family:var(--serif);font-size:27px}.close-dialog{width:36px;height:36px;border:1px solid #b7c8c8;background:none;color:var(--ink);display:grid;place-items:center;font-size:22px;line-height:1}.search-note{font-size:12px;color:var(--muted);line-height:1.8;margin-bottom:20px}.search-field{display:flex;align-items:center;gap:12px;border-bottom:2px solid var(--deep);padding:8px 0 10px}.search-field input{width:100%;min-width:0;border:0;background:transparent;font-size:19px;color:var(--ink);outline:none;min-height:40px}.search-field:focus-within{box-shadow:0 3px #4a93b6}.search-field svg{color:var(--muted)}.search-results{list-style:none;padding:0;margin:15px 0;display:grid}.search-results li{border-bottom:1px solid var(--line)}.search-results a{display:block;padding:15px 0;font-size:15px;line-height:1.65}.search-results a span{display:block;color:var(--muted);font-size:11px;margin-bottom:5px}.search-results a:hover{color:var(--copper)}.empty-state{font-size:14px;line-height:1.9;padding:20px 0;color:var(--muted)}.search-full{display:flex;justify-content:space-between;align-items:center;gap:20px;border-top:1px solid var(--line);padding-top:17px;font-size:13px;font-weight:650}.search-full svg{width:20px}.toast{position:fixed;bottom:25px;left:50%;transform:translate(-50%,15px);max-width:min(480px,calc(100vw - 30px));padding:15px 20px;background:var(--deep-2);color:white;box-shadow:0 5px 30px #12313c30;font-size:13px;line-height:1.8;opacity:0;pointer-events:none;transition:opacity .25s,transform .25s;z-index:90}.toast.is-visible{opacity:1;transform:translate(-50%,0)}
html.show-notes [data-change]{outline:2px solid var(--copper);outline-offset:7px}html.show-notes [data-change]::before{content:attr(data-change);position:absolute;top:0;left:0;transform:translateY(-100%);background:var(--copper);padding:4px 10px;color:white;font:12px var(--sans);z-index:12;pointer-events:none}.recent-section[data-change],.series-layout[data-change]{position:relative}.subscribe-panel[data-change]::before{z-index:12}html.show-notes .subscribe-panel[data-change]::before{top:8px;left:12px;transform:none}.view-notice{position:fixed;bottom:0;left:0;right:0;background:#f4f7f1;color:#5c7375;font-size:10px;text-align:center;z-index:99;padding:4px;display:none}
@media(min-width:1580px){.wrap{width:min(1400px,calc(100% - 128px))}.feature-copy{padding:42px 44px}.feature-copy h2{font-size:38px}.feature-copy h2 .drugname{font-size:57px}.feature-copy .lede{font-size:14px}.lead-feature{min-height:545px}.news-card h3{font-size:18px}}
@media(max-width:1160px){.wrap{width:calc(100% - 64px)}.nav-links{gap:15px}.nav-links a,.nav-search{font-size:12px}.brand span{font-size:19px}.nav-inner{gap:15px}.feature-copy{padding:28px 29px}.feature-copy h2{font-size:29px}.feature-copy h2 .drugname{font-size:44px}.feature-copy .lede{font-size:12px}.lead-feature{min-height:480px}.edition-title h2{font-size:44px}.news-card{padding:17px 17px}.news-card h3{font-size:15px}.series-layout{gap:25px}.series-panel{padding:28px 30px}.series-panel h3{font-size:31px}.series-panel .description{font-size:15px}.series-name{font-size:18px}.series-tab{gap:11px;padding:15px 13px}.subscribe-panel h2{font-size:32px}.subscribe-panel{padding:35px;gap:30px}.footer-top{flex-direction:column;gap:17px}.footer-links{justify-content:flex-start;max-width:100%}}
@media(max-width:960px){.nav-links{display:none;position:absolute;top:100%;left:0;right:0;padding:18px 32px 24px;background:var(--paper);border-bottom:1px solid var(--line);box-shadow:0 12px 20px #12313c0b;grid-template-columns:repeat(3,1fr);gap:5px 25px}.nav-links.is-open{display:grid}.nav-links a,.nav-search{padding:16px 10px;font-size:14px}.nav-links .nav-search{display:none}.mobile-actions{display:flex}.nav-inner{height:68px}.brand span{font-size:20px}.brand img{width:34px;height:34px}.edition-right p{display:none}.lead-feature{grid-template-columns:1fr 1fr;min-height:480px}.feature-copy{padding:27px 25px}.feature-copy h2{font-size:28px}.feature-copy h2 .drugname{font-size:38px}.feature-copy .lede{font-size:12px;line-height:1.85}.feature-actions .section-wordmark{display:none}.art-topline,.art-bottomline{left:20px;right:20px}.art-topline{font-size:9px}.news-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.news-card{padding:21px}.news-card:first-child{padding-left:21px}.news-card:last-child{padding-right:21px}.news-card:nth-child(2){border-right:0}.news-card:nth-child(-n+2){border-bottom:1px solid var(--line)}.news-card h3{font-size:17px}.series-layout{grid-template-columns:minmax(0,.9fr) minmax(0,1.1fr);gap:20px}.series-tab{grid-template-columns:27px 1fr 25px;gap:10px;min-height:76px;padding:15px 13px}.series-name{font-size:17px}.series-tab .circle-arrow{width:25px;height:25px}.series-panel{padding:29px 25px}.series-panel h3{font-size:29px}.series-panel .description{font-size:14px}.panel-number{font-size:130px;right:15px}.editorial-layout{grid-template-columns:140px 1fr;gap:20px}.editorial-copy h2{font-size:24px}.subscribe-panel{grid-template-columns:1fr;gap:24px}.subscribe-action>span{display:none}.subscribe-panel h2{font-size:36px}.social-row{align-items:flex-start}.social-links{gap:15px}}
@media(max-width:700px){html{scroll-padding-top:84px}.wrap{width:calc(100% - 40px)}.nav-inner{height:64px}.brand span{font-size:17px}.brand img{width:31px;height:31px}.brand{gap:8px}.mobile-actions{gap:1px}.nav-menu{min-height:40px;font-size:12px;padding:0 10px}.mobile-search{width:36px}.edition-heading{padding:25px 0 20px;gap:12px}.edition-title{gap:12px}.edition-title h2{font-size:33px;letter-spacing:-.025em}.edition-en{font-size:20px}.edition-right{padding-bottom:2px}.edition-right .text-link{font-size:11px;gap:6px}.edition-right .text-link svg{width:16px}.lead-feature{display:flex;flex-direction:column;min-height:0}.feature-art{min-height:0;aspect-ratio:16 / 10;width:100%}.feature-image{width:100%;height:100%;object-fit:contain}.art-topline{top:15px;left:17px;right:17px;font-size:8px}.art-topline span:first-child{gap:6px}.art-topline span:first-child::before{width:5px;height:5px}.art-bottomline{bottom:13px;left:17px;right:17px;font-size:9px}.art-open{width:30px;height:30px}.art-open svg{width:17px}.feature-copy{padding:26px 25px 28px}.feature-meta{font-size:10px;gap:12px;margin-bottom:14px}.feature-copy h2{font-size:28px;line-height:1.5;letter-spacing:-.04em;margin-bottom:17px}.feature-copy h2 .drugname{font-size:41px;line-height:1.1;margin-bottom:10px;letter-spacing:-.04em}.feature-copy .lede{font-size:13px;line-height:1.95;margin-bottom:23px;color:#c4d5d7}.read-button{min-height:45px;padding:0 16px;font-size:12px;gap:34px}.feature-actions .section-wordmark{display:block;font-size:12px}.recent-section{padding:30px 0 31px}.section-heading{margin-bottom:17px}.section-heading h2{font-size:25px}.section-heading h2 small{font-size:13px;margin-left:9px}.section-heading .text-link{font-size:11px;gap:4px}.news-grid{grid-template-columns:1fr}.news-card,.news-card:first-child,.news-card:last-child{padding:18px 0;border-right:0;border-bottom:1px solid var(--line)}.news-card:last-child{border-bottom:0}.news-meta{margin-bottom:7px}.news-meta time{font-size:11px}.news-number{font-size:22px}.news-card h3{font-size:17px;line-height:1.65;margin-bottom:11px}.news-cta{font-size:11px}.series-section{padding:37px 0}.series-heading{align-items:flex-start;gap:10px;flex-direction:column;margin-bottom:18px}.series-heading h2{font-size:31px}.series-heading p{font-size:12px}.series-layout{display:block}.series-tabs{flex-direction:row;border-top:0;margin:0 -20px;padding:0 20px;overflow-x:auto;scrollbar-width:thin;scrollbar-color:#b3c4be transparent;scroll-snap-type:x proximity;gap:7px;padding-bottom:11px}.series-tab{display:flex;align-items:center;gap:10px;white-space:nowrap;flex-shrink:0;min-height:47px;border:1px solid var(--line);padding:10px 13px;scroll-snap-align:center}.series-index{font-size:17px}.series-name{font-size:14px}.series-tab .circle-arrow{display:none}.series-panel{margin-top:7px;padding:27px 25px;min-height:295px}.panel-number{font-size:120px;top:10px;right:21px}.series-panel .eyebrow{font-size:9px;margin-bottom:24px}.series-panel h3{font-size:29px;margin-bottom:13px}.series-panel .description{font-size:14px;line-height:1.9;min-height:5.3em}.series-panel .series-link{margin-top:13px;font-size:12px}.series-help{flex-direction:column;gap:12px;margin-top:18px;font-size:11px}.series-help .text-link{margin-left:0;font-size:12px}.editorial-section{padding:30px 0}.editorial-layout{grid-template-columns:1fr;gap:14px}.editorial-label{padding-top:0;display:flex;align-items:center;gap:16px}.editorial-label .eyebrow{font-size:9px}.editorial-label p:last-child{margin:0;font-size:16px}.editorial-copy h2{font-size:23px;line-height:1.65;letter-spacing:0}.editorial-links{gap:21px;margin-top:18px;font-size:11px}.editorial-links svg{width:12px;height:12px}.subscribe-section{padding:32px 0}.subscribe-panel{padding:29px 25px;gap:24px}.subscribe-panel h2{font-size:29px;line-height:1.5;margin-bottom:17px}.subscribe-panel h2 span{display:block}.subscribe-panel .subscription-copy{font-size:13px;line-height:1.95}.subscribe-panel .eyebrow{font-size:9px}.subscribe-action .read-button{min-height:46px;font-size:12px}.social-row{flex-direction:column;gap:13px;padding-top:21px}.social-row p{font-size:11px}.social-links{font-size:11px;gap:15px}.social-links svg{width:12px;height:12px}.site-footer{padding:23px 0}.footer-top{font-size:10px;line-height:1.9;gap:15px}.footer-links{gap:12px;font-size:11px}.privacy-row{align-items:flex-start;gap:14px;font-size:9px;flex-direction:column}.privacy-links{font-size:10px}.search-dialog{padding:22px}.search-title h2{font-size:24px}.search-field input{font-size:17px}.nav-links{padding:17px 20px 22px;grid-template-columns:repeat(2,1fr)}.nav-links a{font-size:14px}.view-notice{font-size:9px}}
@media(max-width:359px){.wrap{width:calc(100% - 28px)}.brand span{font-size:15px}.brand img{width:29px}.nav-menu{padding:0 8px}.mobile-search{width:29px}.edition-title h2{font-size:30px}.edition-en{font-size:17px}.feature-copy{padding:23px 20px}.feature-copy h2{font-size:25px}.feature-copy h2 .drugname{font-size:36px}.feature-copy .lede{font-size:12px}.section-heading h2 small{display:none}.social-links{gap:10px}.series-tabs{margin:0 -14px;padding-left:14px;padding-right:14px}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*,*::before,*::after{animation:none!important;transition:none!important}.feature-image{transform:none!important}}

/* Search-ready additions: source HTML remains complete without JavaScript. */
.brand-context{padding:23px 0 0;display:flex;gap:24px;align-items:baseline}.brand-context h1{font-size:16px;font-weight:750;white-space:nowrap}.brand-context p{font-size:12px;color:var(--muted);line-height:1.8;max-width:780px}.search-by-topic{padding:12px 0 42px}.search-by-topic h2{font:700 27px var(--serif);margin-bottom:18px}.topic-paths{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:18px}.topic-path{display:block;border-top:2px solid var(--deep);padding:17px 0}.topic-path h3{font-size:17px;margin-bottom:7px}.topic-path p{font-size:13px;color:var(--muted);line-height:1.9}.topic-path:hover h3{color:var(--copper)}.series-panels{min-width:0}.series-panels .series-panel+.series-panel{margin-top:16px}.tabs-ready .series-panel[hidden]{display:none}.tabs-ready .series-panels .series-panel{margin-top:0}.series-panel h3{scroll-margin-top:90px}.no-js-nav{display:none}html:not(.js) .nav-menu{display:none}html:not(.js) .series-tabs{display:none}html:not(.js) .series-layout{display:block}html:not(.js) .series-panels{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:18px}html:not(.js) .series-panel{margin:0}.search-field{display:flex;gap:12px;align-items:center}.search-submit{border:0;padding:10px 15px;background:var(--deep);color:white;white-space:nowrap}.research-access{font-size:12px;color:var(--muted);padding-top:12px}.research-access a{text-decoration:underline;text-underline-offset:4px}.preview-ribbon{position:relative;padding:12px 20px;background:#e9f1ee;color:#143d46;display:flex;align-items:center;justify-content:space-between;gap:14px;font:12px/1.8 var(--sans);border-bottom:1px solid #c8d7d1}.preview-ribbon details{max-width:600px}.preview-ribbon summary{cursor:pointer;font-weight:700}.preview-ribbon p{margin-top:8px}.preview-ribbon a{text-decoration:underline}.js .nav-links{transition:none}.feature-copy h2{overflow-wrap:anywhere}.feature-image{aspect-ratio:16/9}.feature-art picture{display:contents}
@media(max-width:960px){html:not(.js) .nav-links{display:flex;position:static;flex-wrap:wrap;box-shadow:none;padding:8px 0;border:0;gap:10px}html:not(.js) .nav-inner{height:auto;display:block;padding:15px 0}html:not(.js) .nav-links a{padding:7px 0;font-size:12px}.topic-paths{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media(max-width:700px){.brand-context{display:block;padding-top:17px}.brand-context h1{font-size:15px;margin-bottom:5px}.brand-context p{font-size:11px}.search-by-topic{padding-bottom:26px}.search-by-topic h2{font-size:24px}.topic-paths{gap:12px}.topic-path h3{font-size:15px}.topic-path p{font-size:12px}.preview-ribbon{font-size:10px;align-items:flex-start;padding:9px 16px}.preview-ribbon .ribbon-meta{display:none}html:not(.js) .series-panels{grid-template-columns:1fr}}
/* Keep labels outside an existing cover's printed text on narrow screens. */
@media(max-width:700px){.feature-art{aspect-ratio:auto;flex-direction:column;gap:10px;padding:12px 0}.art-topline,.art-bottomline{position:static;width:calc(100% - 34px)}.feature-image{height:auto}}
html:not(.js) .nav-links .nav-search{display:flex}
.feature-copy h2{text-wrap:balance;line-height:1.45}

.title-text{display:block;text-wrap:balance}